Remodelling of trabecular bone in human distal tibia: A model based on an in-vivo HR-pQCT study

An abnormal remodelling process of bones can lead to various bone disorders, such as osteoporosis, making them prone fracture. Simulations load-induced trabecular were used investigate its response mechanical signal. However, the role mechanostat in trabecular-bone has not yet been investigated simulations underpinned by a longitudinal in-vivo study humans. In this work, finite-element model based on 6-month HR-pQCT was developed and validated effect stimuli remodelling. The simulated changes microstructural parameters density compared with respective experimental results. A maximum principal strain (MPS) gradient (∇MPS) signals drive five-stage model, including additional over-strain damage stages. It found that distribution varied studied signals, along decreasing time levels volume fraction BV/TV, thickness Tb.Th surface area Tb.BS well increased separation Tb.Sp. Among these parameters, BV/TV together bone-remodelling from MPS demonstrated significant correlation data. provides good foundation for further development investigation relationships between loading human-bone microarchitecture.